Definition of Glanzmann's disease:

Glanzmann' s disease is a rare disorder of blood platelets, which results in easy bruising and nosebleeds.

Causes, incidence, and risk factors:

Glanzmann's disease is caused by the lack of a protein that is normally on the surface of platelets, which is needed for them to clump together (aggregate) normally.

The condition is congenital, which means it is present from birth. There are several genetic abnormalities that can cause the condition.

Symptoms:

• Bleeding during and after surgery
• Bleeding gums
• Easy bruising
• Heavy menstrual bleeding
• Nosebleeds (epistaxis)
• Prolonged bleeding with minor injuries

Signs and tests:

The following tests may be used to diagnose this condition:

• Complete blood count (CBC)
• Bleeding time
• Platelet aggregation tests
• Prothrombin time (PT) and partial thromboplastin time (PTT)

Other tests may be needed, including the testing of relatives.

Treatment:

There is no specific treatment for this disorder. Platelet transfusions may be given to patients who are having severe bleeding.

Expectations (prognosis):

Glanzmann's thrombasthenia is a life-long condition for which there is no cure. Patients should take precautions to avoid bleeding.

Anyone with a bleeding disorder should avoid taking aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen. These drugs can prolong bleeding times and prevent platelets from activating and aggregating.

Complications:

• Severe bleeding
• Iron deficiency anemia in menstruating women

Calling your health care provider:

Call your health care provider if:

• You have bleeding or bruising of an unknown cause
• Bleeding does not stop after usual treatments

Prevention:

A blood test can detect the gene responsible for the condition.

Genetic counseling may be helpful to couples with a family history of platelet disorders who are planning to have children in the future.