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Hyperimmunoglobulin E syndrome - Symptom

Alternative Names

Job syndrome; Hyper IgE syndrome

Symptoms:

  • Bone and tooth defects, including fractures and losing the baby teeth late
  • Eczema
  • Skin abscesses and infection
  • Repeated sinus infections

Signs and tests:

An eye exam may reveal signs of dry eye syndrome. A physical exam may show:

A chest x-ray may reveal lung abscesses.

Tests used to confirm the diagnosis include:

Other tests that may be done:

A scoring system that combines the different problems of Job syndrome is used to help make the diagnosis.

  • Reviewed last on: 8/1/2011
  • John A. Daller, MD, PhD, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Genetics Home Reference (GHR). Job Syndrome. Feb 2008. Accessed Nov. 13, 2008.

Immune Deficiency Foundation. Immune Deficiency Foundation Patient & Family Handbook. Chapter 12: Hyper IgE Syndrome. 4th ed. 2007. Accessed Nov. 13, 2008.

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