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Hyperimmunoglobulin E syndrome

• Overview
• Symptoms
• Treatment
• Prevention

Alternative Names:

Job syndrome; Hyper IgE syndrome

Treatment:

There is no known cure for the condition. The goal of treatment is to control the recurrent infections. Medications include antibiotic treatment. Antifungal agents and antiviral agents are prescribed when appropriate.

Sometimes, surgical drainage of abscesses is needed.

IV gamma globulin may help to build up the immune system temporarily when there are severe infections.

Expectations (prognosis):

Job syndrome is a lifelong chronic condition. Each new infection requires treatment.

Complications:

• Repeated infections
• Sepsis

Calling your health care provider:

Call your health care provider if you are experiencing or observing a collection of the above signs and symptoms.

References:

Cohen J, Powderly WG. Infectious Diseases . 2nd ed. New York, NY: Elsevier; 2004.

Hoffman R, Benz EJ, Shattil SS, et al. Hematology: Basic Principles and Practice . 4th ed. Orlando, Fl: Churchill Livingstone; 2005.

• Review Date: 7/25/2007
• Reviewed By: Donald Accetta, MD, MPH, President, Allergy & Asthma Care, PC, Taunton, MA. Review provided by VeriMed Healthcare Network.

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