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Malignant hyperthermia is an inherited disease that causes a rapid rise in body temperature ( fever ) and severe muscle contractions when the affected person receives general anesthesia .
This condition is not the same as hyperthermia due to medical emergencies such as heat stroke .
Malignant hyperthermia is an autosomal dominant trait, meaning it requires only one parent carrying the disease for a child to inherit the condition. It may be associated with muscular diseases such as multiminicore myopathy and central core disease.
One form of malignant hyperthermia is caused by a defect in the ryanodine receptor (RYR1) gene
Marx J. Rosen’s Emergency Medicine: Concepts and Clinical Practice . 5th ed. St. Louis, Mo: Mosby; 2002:2000.
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