General symptoms include:
A physical examination may show signs of inflammation of the brain and its covering, the meninges (meningoencephalitis).
Tests include the following:
Most antibody and antigen tests are not very helpful because they cannot tell the difference between current and past infection. Specific IgM levels in the cerebrospinal fluid may be helpful, however.
Kirchoff LV. Agents of African trypanosomiasis (sleeping sickness). In: Mandell GL, Bennett JE, Dolan R, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th ed. Orlando, FL: Saunders Elsevier;2009:chap 278.
Quinn TC. African trypanosomiasis (sleeping sickness). In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 367.
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