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Chagas disease - Treatment

Alternative Names

American trypanosomiasis

Treatment:

The acute phase and reactivated Chagas disease should be treated. Infants born with the infection should also be treated.

Treating the chronic phase is recommended for both children and adults. Adult patients should talk to their doctor about whether to treat chronic Chagas disease.

Two drugs are used to treat this infection: benznidazole and nifurtimox.

Both drugs often have side effects. The side effects may be worse in older people.

Side effects may include:

  • Headaches and dizziness
  • Loss of appetite and weight loss
  • Neuropathy
  • Problems sleeping
  • Skin rashes

Expectations (prognosis):

About 30% of infected people who are not treated will develop chronic or symptomatic Chagas disease. It may take more than 20 years from the time of the original infection to develop heart or digestive problems.

Abnormal heart rhythms (arrhythmias, ventricular tachycardia) may cause sudden death. Once heart failure develops, death usually occurs within several years.

Complications:

  • Cardiomyopathy
  • Enlargement of the colon (megacolon)
  • Enlargement of the esophagus (megaesophagus) with swallowing difficulty
  • Heart disease
  • Heart failure
  • Malnutrition

Calling your health care provider:

Call for an appointment with your health care provider if you may be infected with Chagas disease.

  • Reviewed last on: 9/28/2008
  • Jatin M. Vyas, PhD, MD, Instructor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Neva FA. American trypanosomiasis (Chagas' disease). In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier, 2007;chap 368.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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