Definition of Multiple lentigines syndrome:

Multiple lentigines syndrome is an inherited disorder identified by an increased number of lentigines (freckle-like spots).

Causes, incidence, and risk factors:

Multiple lentigines syndrome is inherited as an autosomal dominant trait. People with this condition have large numbers of lentigines. Lentigines are skin markings that are somewhat darker than true freckles. They are present from birth. They are located mostly on the trunk and neck.

Symptoms:

Symptoms of multiple lentigines include:

• Abnormal genitalia
• Absent or delayed puberty
• Cafe-au-lait spots (light brown birthmarks)
• Hearing problems (partial deafness)
• Hypogonadism
• Multiple spots on neck and trunk
• Pectus carinatum (abnormalities of the sternum or breastbone)
• Pectus excavatum
• Prominent ears
• Slow growth
• Undescended testicles (cryptorchidism)
• Wide-set eyes (hypertelorism)

Note: Scattered lentigines is normal and does not indicate a problem.

Signs and tests:

The health care provider will perform a physical exam and listen to your heart with a stethoscope. There may be signs of a heart valve problems or obstructive cardiomyopathy.

Tests that may be done can include:

• ECG
• Hearing test
• CT scan of the brain
• Skull x-ray
• EEG

Treatment:

Symptoms are treated as appropriate. A hearing aid may be needed. Hormone treatment may be necessary at the expected time of puberty to cause the normal changes to occur.

Laser or bleaching creams may help lighten some of the brown spots on the skin.

Expectations (prognosis):

Most patients adjust very well with proper attention to their specific problems.

Complications:

Complications vary and include:

• Deafness
• Delayed puberty
• Heart problems
• Infertility

Calling your health care provider:

Call your health care provider if there are symptoms of this disorder.

Call for an appointment with your health care provider if you have a family history of this disorder and plan to have children.

Prevention:

Genetic counseling is recommended for people with a family history of multiple lentigines syndrome who want to have children.