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Multiple lentigines syndrome - Symptom

Alternative Names

Leopard syndrome

Symptoms:

A family history of multiple lentigines
Absent or delayed puberty
Cafe-au-lait spots
Multiple lentigines on neck and trunk (may be on any cutaneous surface)
Pectus carinatum (abnormalities of the sternum or breastbone)
Pectus excavatum
Prominent ears
Slow growth
Undescended testicles (cryptorchidism)
Wide-set eyes (hypertelorism)

Signs and tests:

A physical examination may show signs of mild pulmonic stenosis (obstruction of the pulmonic heart valve) and obstructive cardiomyopathy.

Tests:

ECG, may show abnormalities
Endocrine evaluation
Hearing test

Pectus excavatum

Reviewed last on: 4/15/2009
Jonathan Kantor, MD, North Florida Dermatology Associates, Jacksonville, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Gibbs NF, Makkar HS. Disorders of Hyperpigmentation and Melanocytes. In: Eichenfield LF, Frieden IJ, Esterly NB, eds. Textbook of Neonatal Dermatology. 2nd Ed. Philadelphia, Pa: Saunders Elsevier; 2001: p. 196.

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