Symptoms:

Reye syndrome often begins with vomiting, which lasts for many hours. The vomiting is quickly followed by irritable and aggressive behavior. As the condition gets worse, the child may be unable to stay awake and alert.

Other symptoms of Reye syndrome:

• Confusion
• Lethargy
• Loss of consciousness or coma
• Mental changes
• Nausea and vomiting
• Seizures
• Unusual placement of arms and legs (decerebrate posture) -- the arms are extended straight and turned toward the body, the legs are held straight, and the toes are pointed downward

Other symptoms that can occur with this disorder include:

• Double vision
• Hearing loss
• Muscle function loss or paralysis of the arms or legs
• Speech difficulties
• Weakness in the arms or legs

Signs and tests:

The following tests may be used to diagnose Reye syndrome:

• Blood chemistry tests
• Head CT or head MRI scan
• Liver biopsy
• Liver function tests
• Serum ammonia test
• Spinal tap

Treatment:

There is no specific treatment for this condition. The health care provider will monitor the pressure in the brain, blood gases, and blood acid-base balance (pH).

Treatments may include:

• Breathing support (a breathing machine may be needed during a deep coma)
• Fluids by IV to provide electrolytes and glucose
• Steroids to reduce swelling in the brain

Expectations (prognosis):

How well a person does depends on the severity of any coma, as well as other factors.

The outcome for those who survive an acute episode may be good.

Complications:

• Coma
• Permanent brain damage
• Seizures

Untreated, seizures and coma may be life-threatening.

Calling your health care provider:

Go to the emergency room or call the local emergency number (such as 911) immediately if your child has confusion, lethargy, or other mental changes.

Prevention:

Never give a child aspirin unless told to do so by your doctor.

When a child must take aspirin, take care to reduce the child's risk of catching a viral illness such as the flu and chickenpox. Avoid aspirin for several weeks after the child has received a varicella (chickenpox) vaccine.

Note: Other over-the-counter medications, such as Pepto-Bismol and substances with oil of wintergreen also contain aspirin compounds called salicylates. Do not give these to a child who has a cold or fever.