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Anencephaly - Overview

Alternative Names

Aprosencephaly with open cranium

Definition of Anencephaly:

Anencephaly is the absence of a large part of the brain and the skull.

Causes, incidence, and risk factors:

Anencephaly is one of the most common neural tube defects. Neural tube defects are birth defects that affect the tissue that grows into the spinal cord and brain. Anencephaly occurs early in the development of an unborn baby. It results when the upper part of the neural tube fails to close. Why this happens is not known. Possible causes include environmental toxins and low intake of folic acid during pregnancy.

Anencephaly occurs in about 4 out of 10,000 births. The exact number is unknown, because many of these pregnancies result in miscarriage. Having one infant with this condition increases the risk of having another child with neural tube defects.

  • Reviewed last on: 7/26/2007
  • Daniel Rauch, M.D., FAAP., Director, Pediatric Hospitalist Program, New York University School of Medicine, New York, NY. Review provided by VeriMed Healthcare Network.