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Newborns with this disorder:
Other symptoms include:
Affected children have an intense craving for food and will do almost anything to get it. This results in uncontrollable weight gain and morbid obesity. Morbid obesity may lead to lung failure, which includes low blood oxygen levels, right-sided heart failure, and death.
Signs of Prader-Willi syndrome may be seen at birth.
As the child grows older, laboratory tests may show signs of morbid obesity, such as:
There may also be signs of right-sided heart failure and knee and hip problems.
Saitta SC, Ackai EH. Specific chromosome disorders in newborns. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 20.
McCandless SE; Committee on Genetics. Clinical report -- health supervision for children with Prader-Willi syndrome. Pediatrics. 2011; 127(1):195-204.
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