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Osteosarcoma - Treatment

Alternative Names

Osteogenic sarcoma

Treatment:

Treatment usually starts after a biopsy of the tumor is done.

Before major surgery to remove the tumor, chemotherapy is usually given. This can shrink the tumopr and it makes surgery easier. It also may kill any cancer cells that have spread to other parts of the body.

Common chemotherapy medicines include:

  • Cisplatin
  • Carboplatin (Paraplatin)
  • Cyclophosphamide (Cytoxan)
  • Doxorubicin (Adriamycin)
  • High-dose methotrexate with leucovorin
  • Ifosfamide (Ifex)

Surgery is used after chemotherapy to remove any remaining tumor. In most cases, surgery can remove the tumor while saving the affected limb (this is called limb-salvage surgery). Rarely, more radical surgery (such as amputation) may be necessary.

Support Groups:

Association of Cancer Online Resources -- www.acor.org

Cure Search for Children's Cancer --www.curesearch.org

Expectations (prognosis):

If the tumor has not spread to the lungs (pulmonary metastasis), long-term survival rates are better. If the cancer has spread to other parts of the body, prognosis is better but there is still a chance of cure with effective treatment.

Complications:

  • Limb removal
  • Spread of cancer to the lungs
  • Side effects of chemotherapy

Calling your health care provider:

Call your health care provider if you have persistent bone pain, tenderness, or swelling.

  • Reviewed last on: 3/18/2011
  • A.D.A.M. Editorial Team: David Zieve, MD, MHA, and David R. Eltz. Previously reviewed by David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital (12/28/2010).

References

Baker MH. Bone tumors: primary and metastatic bone lesions. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 212.

Gebhardt MC, Springfield D, Neff JR. Sarcomas of the bone. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone, 2008;chap 96.

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