
No specific treatment exists for Lesch-Nyhan syndrome. The gout medication allopurinol successfully decreases uric acid levels, but does not improve the neurological outcome.
Some symptoms may be relieved with the drugs carbidopa/levodopa, diazepam, phenobarbital, or haloperidol.
The outcome is likely to be poor. Persons with this syndrome usually require assistance walking and sitting and generally need a wheelchair to get around.
Severe, progressive disability is likely.
Call your health care provider if signs of this illness appear in your child or if there is a history of Lesch-Nyhan syndrome in your family.
Harris J. Disorders of Purine and Pyrimidine Metabolism.In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007: Chap. 89.