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Mucopolysaccharides - Overview

Overview

Alternative Names

Glycosaminoglycans; GAG

Definition of Mucopolysaccharides:

Mucopolysaccharides are long chains of sugar molecules that are found throughout the body, often in mucus and in fluid around the joints. They are more commonly called glycosaminoglycans.

Information:

When the body cannot break down mucopolysaccharides, a condition called mucopolysaccharidoses (MPS) occurs. MPS refers to a group of inherited disorders of metabolism. People with MPS do not have any, or enough of a substance (enzyme) needed to break down the sugar molecule chains.

Forms of MPS include:

These conditions cause mucopolysaccharides to build up in body tissues. This can damage organs, including the heart. Symptoms can range from mild to severe and may include:

Abnormal features of the face
Bone, cartilage, and connective tissue deformities
Mental retardation

Reviewed last on: 10/14/2009
Luc Jasmin MD, PhD, Departments of Anatomy and Neurological Surgery, University of California, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

National Institute of Neurological Disorders and Stroke. Mucolipidoses Fact Sheet. Office of Communications and Public Liaison. Bethesda, MD; Publication No. 03-5115. February 13, 2007.

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