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Nicotinic acid; Vitamin B3
Niacin is a type of B vitamin. It is water-soluble, which means it is not stored in the body. Water-soluble vitamins dissolve in water. Leftover amounts of the vitamin leave the body through the urine. That means you need a continuous supply of such vitamins in your diet.
Niacin helps the digestive system, skin, and nerves to function. It is also important for converting food to energy.
Niacin (also known as vitamin B3) is found in:
Niacin and Cardiovascular Disease
Under the supervision of a health care provider, you can take doses of 1 to 3 grams of nicotinic acid per day to treat low HDL cholesterol and high LDL cholesterol and triglyceride levels. When used to treat blood fats (lipids), the nicotinic acid is usually divided into three or four doses spread throughout the day. Nicotinamide does not affect blood lipids.
A deficiency of niacin causes pellagra. The symptoms include:
Large doses of niacin can cause:
Even normal doses can be associated with skin flushing. New forms of nicotinic acid reduce this side effect. Nicotinamide does not cause these side effects.
Reference Intakes
Recommendations for niacin and other nutrients are provided in the Dietary Reference Intakes (DRIs), which are developed by the Food and Nutrition Board at the Institute of Medicine. DRI is the term for a set of reference values that are used to plan and assess the nutrient intakes of healthy people. These values, which vary by age and gender, include:
Dietary Reference Intakes for Niacin:
Infants
*Adequate Intake (AI)
Children
Adolescents and Adults
Specific recommendations depend on age, gender, and other factors (such as pregnancy). Women who are pregnant or breast-feeding need higher amounts. Ask your health care provider which amount is best for you.
The best way to get the daily requirement of essential vitamins is to eat a balanced diet that contains a variety of foods.
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Sarubin Fragaakis A, Thomson C. The Health Professional's Guide to Popular Dietary Supplements. 3rd ed. Chicago, Il: American Dietetic Association; 2007.
Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, PantothenicAcid, Biotin, and Choline. National Academy Press, Washington, DC, 1998.
Cervantes-Laurean D, McElvaney NG, Moss J. Niacin. In: Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md. Williams & Wilkins; 1999:401-411.
Malik S, Kashyap ML. Niacin, lipids, and heart disease. Curr Cardiol Rep. 2003;5:470-476.
McKenny J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med; 2004;164:697-705.
Grundy SM, Vega GL, McGovern ME, et al. Efficacy, safety, tolerability of once-daily niacin for the treatmetn of dyslipidemia associated with type 2 diabetes control and evaluation and efficiency of Niaspan trial. Arch Intern Med. 2002;162:1568-1576.
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