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Nicotinic acid; Vitamin B3
A deficiency of niacin causes pellagra. The symptoms include:
Large doses of niacin can cause:
Even normal doses can be associated with skin flushing. New forms of nicotinic acid reduce this side effect. Nicotinamide does not cause these side effects.
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Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, PantothenicAcid, Biotin, and Choline. National Academy Press, Washington, DC, 1998.
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McKenny J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med; 2004;164:697-705.
Grundy SM, Vega GL, McGovern ME, et al. Efficacy, safety, tolerability of once-daily niacin for the treatmetn of dyslipidemia associated with type 2 diabetes control and evaluation and efficiency of Niaspan trial. Arch Intern Med. 2002;162:1568-1576.
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