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Aminophylline overdose - Symptom

Alternative Names

Theophylline overdose; Xanthine overdose

Symptoms:

The major life-threatening events of theophylline intoxication are seizures and heart rhythm disturbances.

Symptoms in adults may include:

  • Gastrointestinal
    • Increased appetite
    • Increased thirst
    • Nausea
    • Vomiting (possibly with blood)
  • Heart and blood
  • Lungs
  • Muscles and joints
    • Muscle twitching and cramping
  • Nervous system
    • Confusion
    • Convulsions
    • Dizziness
    • Fever
    • Hallucinations (thinking something is there, but it's not)
    • Headache
    • Irritability
    • Psychosis
    • Restlessness
    • Sweating
    • Trouble sleeping

Symptoms in babies may include:

  • Gastrointestinal
    • Nausea
    • Vomiting
  • Heart and blood
    • Irregular heartbeat
    • Low blood pressure
    • Rapid heartbeat
    • Shock
  • Lungs
    • Rapid, deep breathing
  • Muscles and joints
  • Nervous system
    • Convulsions
    • Irritability
    • Tremors
  • Reviewed last on: 2/3/2009
  • Jacob L. Heller, MD, MHA, Emergency Medicine, Virginia Mason Medical Center, Seattle, Washington. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Shannon MW. Theophylline and caffeine. In: Shannon MW, Borron SW, Burns MJ, eds. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. 4th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 65.

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