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Amitriptyline hydrochloride overdose - All Information

Alternative Names

Elavil overdose; Adepril overdose; Endep overdose; Enovil overdose; Trepiline overdose

Definition of Amitriptyline hydrochloride overdose:

Amitriptyline hydrochloride is a type of prescription medicine called a tricyclic antidepressant. Amitriptyline hydrochloride overdose occurs when someone accidentally or intentionally takes more than the normal or recommended amount of this medication.

Poisonous Ingredient:

Amitriptyline

Where Found:

Amitriptyline hydrochloride is a prescription medication. Brands include:

  • Adepril
  • Amitid
  • Amitril
  • Elavil
  • Emitrip
  • Endep
  • Enovil
  • Trepiline
  • Tryptanol
  • Vanatrip
Note: This list may not be all inclusive.

Symptoms:

Home Treatment:

This can be a very serious overdose. Seek immediate medical help.

Before Calling Emergency:

Determine the following information:

  • Patient's age, weight, and condition
  • Name of the product (ingredients and strengths, if known)
  • Time it was swallowed
  • Amount swallowed
  • If the medication was prescribed for the patient

Poison Control, or a local emergency number:

The National Poison Control Center (1-800-222-1222) can be called from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

See: Poison control center - emergency number

What to expect at the emergency room:

The health care provider will measure and monitor the patient's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated as appropriate.

The patient may receive:

  • Activated charcoal
  • Antidote (sodium bicarbonate)
  • Breathing help, possibly artificial respiration
  • Fluids
  • Laxative
  • Tube through the mouth into the stomach to empty the stomach (gastric lavage)

Expectations (prognosis):

Amitriptyline hydrochloride can be an extremely serious overdose.

Patients who swallow an excessive amount of this drug are almost always admitted to hospital.

How well a patient does depends on how much of the drug was swallowed and how quickly treatment was received. The faster a patient gets medical help, the better the chance of recovery.

  • Reviewed last on: 1/20/2008
  • Eric Perez, MD, Department of Emergency Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Woolf AD, Erdman AR, Nelson LS, et al. American Association of Poison Control Centers. Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol. 2007;45(3):203-33.