Bone marrow transplant - Risks
Alternative Names
Transplant - bone marrow; Stem cell transplant; Hematopoietic stem cell transplant; Reduced intensity, non-myeloablative transplant; Mini transplant; Allogenic bone marrow transplant; Autologous bone marrow transplant; Umbilical cord blood transplant
Risks:
All bone marrow transplants have risks. The risk is higher or lower depending on many factors. Some of these factors are:
- What disease you have
- What type of treatment (chemotherapy, radiation) you have before the bone marrow transplant
- How old you are
- How healthy you are when you have your transplant
- How good a match your donor is
- What type of bone marrow transplant patient you are having (autologous, allogeneic, or umbilical cord blood)
Complications you may have are:
- Infections: these may be very serious.
- Bleeding: this can happen in the lungs, the intestines, brain, and any other part of the body.
- Anemia
- Diarrhea, nausea, and vomiting
- Pain
- Severe mucositis (inflammation and soreness) in the mouth, throat, esophagus, and stomach
- Damage to the kidneys, liver, lungs, and heart
- Cataracts
- Early menopause
- Graft failure, which means that the new cells do not settle into the body and start producing stem cells
- Graft versus host disease: This is when your donorâ ' s cells attack your own body. In the first few months after the transplant, symptoms may be a skin rash, diarrhea, or abnormal liver tests. Later, symptoms may be dry eyes or mouth, tightness of the skin, scarring in the lungs, chronic diarrhea, and other problems.
- Children who get transplants may have delayed growth.
- Reviewed last on: 10/30/2008
- Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
References
Bishop MR, Pavletic SZ. Hematopoietic stem cell transplantation. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKena WG, eds. Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 32.
Vose JM, Pavletic SZ. Hematopoietic stem cell transplantation. In: Goldman L, Ausiello D. Goldman: Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 184.