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Bone marrow transplant - Risks

Alternative Names

Transplant - bone marrow; Stem cell transplant; Hematopoietic stem cell transplant; Reduced intensity, non-myeloablative transplant; Mini transplant; Allogenic bone marrow transplant; Autologous bone marrow transplant; Umbilical cord blood transplant

Risks:

All bone marrow transplants have risks. The risk is higher or lower depending on many factors. Some of these factors are:

  • What disease you have
  • What type of treatment (chemotherapy, radiation) you have before the bone marrow transplant
  • How old you are
  • How healthy you are when you have your transplant
  • How good a match your donor is
  • What type of bone marrow transplant patient you are having (autologous, allogeneic, or umbilical cord blood)

Complications you may have are:

  • Infections: these may be very serious.
  • Bleeding: this can happen in the lungs, the intestines, brain, and any other part of the body.
  • Anemia
  • Diarrhea, nausea, and vomiting
  • Pain
  • Severe mucositis (inflammation and soreness) in the mouth, throat, esophagus, and stomach
  • Damage to the kidneys, liver, lungs, and heart
  • Cataracts
  • Early menopause
  • Graft failure, which means that the new cells do not settle into the body and start producing stem cells
  • Graft versus host disease: This is when your donorâ ' s cells attack your own body. In the first few months after the transplant, symptoms may be a skin rash, diarrhea, or abnormal liver tests. Later, symptoms may be dry eyes or mouth, tightness of the skin, scarring in the lungs, chronic diarrhea, and other problems.
  • Children who get transplants may have delayed growth.
  • Reviewed last on: 10/30/2008
  • Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Bishop MR, Pavletic SZ. Hematopoietic stem cell transplantation. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKena WG, eds. Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 32.

Vose JM, Pavletic SZ. Hematopoietic stem cell transplantation. In: Goldman L, Ausiello D. Goldman: Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 184.

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