What to expect at your health care provider's office:

An infant with a single palmar crease may have other symptoms and signs that, when taken together, define a specific syndrome or condition. Diagnosis of that condition is based on a family history, medical history, and complete physical exam.

Your doctor may ask questions such as:

• Is there a family history of Down syndrome or other disorder associated with a single palmar crease?
• Does anyone else in the family have a single palmar crease without other symptoms?
• Did the mother use alcohol while pregnant?
• What other symptoms do you have?

Based on the answers to these questions, the medical history, and the results of the physical exam, further testing may be necessary.