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Hemoglobin derivatives - Results

Alternative Names

Methemoglobin; Carboxyhemoglobin; Sulfhemoglobin

Normal Values:

The following values represent the percentage of hemoglobin derivatives based on total hemoglobin:

  • Carboxyhemoglobin: less than 3% (but may be as high as 15% in smokers)
  • Methemoglobin: less than 3%
  • Sulfhemoglobin: undetectable

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.

What abnormal results mean:

High levels of hemoglobin derivatives can lead to significant health problems. The altered forms of hemoglobin do not allow oxygen to be moved properly through the body. This can lead to tissue death.

The following values, except sulfhemoglobin, represent the percentage of hemoglobin derivatives based on total hemoglobin:

Carboxyhemoglobin:

  • 10 - 20% symptoms of carbon monoxide poisoning begin to appear
  • 30% severe carbon monoxide poisoning present
  • 50-80% results in deadly carbon monoxide poisoning

Methemoglobin:

  • 10-25% results in cyanosis
  • 35-40% results in shortness of breath and headache
  • Over 60% results in lethargy and stupor
  • Over 70% results in death

Sulfhemoglobin:

  • Values of 10 grams per deciliter (gm/dL) cause bluish skin color due to lack of oxygen (cyanosis), but do not cause harmful effects
  • Reviewed last on: 5/30/2011
  • David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Benz EJ Jr, Ebert BL. Hemoglobin variants associated with hemolytic anemia, altered oxygen affinity, and methemoglobinemias. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2008:chap 44.

Christiani DC. Physical and chemical injuries of the lung. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 94.

Nagel RL. Methemoglobinemias and unstable hemoglobins. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 168.

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