Normal Values:

Following are some of the drugs that are commonly checked, followed by the normal therapeutic levels:

• Acetaminophen: varies with use
• Amikacin: 15 to 25 mcg/mL
• Aminophylline: 10 to 20 mcg/mL
• Amitriptyline: 120 to 150 ng/mL
• Carbamazepine: 5 to 12 mcg/mL
• Chloramphenicol: 10 to 20 mcg/mL
• Desipramine: 150 to 300 ng/mL
• Digoxin: 0.8 to 2.0 ng/mL
• Disopyramide: 2 to 5 mcg/mL
• Ethosuximide: 40 to 100 mcg/mL
• Flecainide: 0.2 to 1.0 mcg/mL
• Gentamicin: 5 to 10 mcg/mL
• Imipramine: 150 to 300 ng/mL
• Kanamycin: 20 to 25 mcg/mL
• Lidocaine: 1.5 to 5.0 mcg/mL
• Lithium: 0.8 to 1.2 mEq/L
• Methotrexate: greater than 0.01 mcmol
• Nortriptyline: 50 to 150 ng/mL
• Phenobarbital: 10 to 30 mcg/mL
• Phenytoin: 10 to 20 mcg/mL
• Primidone: 5 to 12 mcg/mL
• Procainamide: 4 to 10 mcg/mL
• Propranolol: 50 to 100 ng/mL
• Quinidine: 2 to 5 mcg/mL
• Salicylate: 100 to 250 mcg/mL
• Theophylline: 10 to 20 mcg/mL
• Tobramycin: 5 to 10 mcg/mL
• Valproic acid: 50 to 100 mcg/mL

Note:

• mcg/mL = microgram per milliliter
• ng/mL = nanogram per milliliter
• mEq/L = milliequivalents per liter
• mcmol = micromole

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

What abnormal results mean:

Following are toxic levels for some of the drugs that are commonly checked:

• Acetaminophen: greater than 250 mcg/mL
• Amikacin: greater than 25 mcg/mL
• Aminophylline: greater than 20 mcg/mL
• Amitriptyline: greater than 500 ng/mL
• Carbamazepine: greater than 12 mcg/mL
• Chloramphenicol: greater than 25 mcg/mL
• Desipramine: greater than 500 ng/mL
• Digoxin: greater than 2.4 ng/mL
• Disopyramide: greater than 5 mcg/mL
• Ethosuximide: greater than 100 mcg/mL
• Flecainide: greater than 1.0 mcg/mL
• Gentamicin: greater than 12 mcg/mL
• Imipramine: greater than 500 ng/mL
• Kanamycin: greater than 35 mcg/mL
• Lidocaine: greater than 5 mcg/mL
• Lithium: greater than 2.0 mEq/L
• Methotrexate: greater than 10 mcmol over 24-hours
• Nortriptyline: greater than 500 ng/mL
• Phenobarbital: greater than 40 mcg/mL
• Phenytoin: greater than 30 mcg/mL
• Primidone: greater than 15 mcg/mL
• Procainamide: greater than 16 mcg/mL
• Propranolol: greater than 150 ng/mL
• Quinidine: greater than 10 mcg/mL
• Salicylate: greater than 300 mcg/mL
• Theophylline: greater than 20 mcg/mL
• Yobramycin: greater than 12 mcg/mL
• Valproic acid: greater than 100 mcg/mL