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HLA-B27 antigen - Results

Alternative Names

Human leukocyte antigen B27

Normal Values:

A normal (negative) result means HLA-B27 is absent.

However, HLA-B27 is found in 5 - 7% of Caucasians who do not have an autoimmune disorder.

What abnormal results mean:

A positive test means HLA-B27 is present. It suggests a greater-than-average risk for developing:

  • Ankylosing spondylitis
  • Reiter syndrome
  • Sacroiliitis (inflammation of the sacroiliac joint)

In the presence of suggestive clinical findings, a positive HLA-B27 test may confirm the diagnosis.

  • Reviewed last on: 5/21/2009
  • David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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