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Trypsinogen test - Overview

Alternative Names

Serum trypsin; Trypsin-like immunoreactivity; Serum trypsinogen; Immunoreactive trypsin

Definition of Trypsinogen test:

Trypsinogen is a substance that is normally produced in the pancreas and released into the small intestine. Trypsinogen is converted to trypsin. Then it starts the process needed to break down proteins into their building blocks (called amino acids).

A test can be done to measure the amount of trypsinogen in your blood.

How the test is performed:

A blood sample is needed. For information on how this is done, see: Venipuncture.

The blood is then tested in a laboratory.

How to prepare for the test:

There are no special preparations.

How the test will feel:

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the test is performed:

This test is done to detect diseases of the pancreas. However, it is no better than other tests, such as blood amylase or lipase for acute pancreatitis.

It is also ordered during routine newborn screening tests to check for cystic fibrosis.

Blood test

Reviewed last on: 2/4/2011
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program San Diego, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Forsmark CE. Chronic pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisinger and Fordtranâ€™s Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 59.

Tenner S, Steinberg WM. Acute pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisinger and Fordtranâ€™s Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 58.

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