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CSF-VDRL test - Overview

Alternative Names

Venereal disease research laboratory slide test - CSF

Definition of CSF-VDRL test:

The CSF-VDRL test is used to diagnose neurosyphilis. This test looks for antibodies called reagins, which are sometimes produced by the body in reaction to the syphilis-causing bacteria.

How the test is performed:

The test is performed on a CSF sample obtained by lumbar puncture (spinal tap).

How to prepare for the test:

Before the procedure, you will be asked to review the risks and sign a consent form.

How the test will feel:

Usually, discomfort associated with the lumbar puncture is mild to moderate. The entire procedure usually takes about 30 minutes but may take longer. The actual fluid collection only takes a few minutes.

Why the test is performed:

The CSF-VDRL test is used to diagnose syphilis in the brain or spinal cord. Brain and spinal cord involvement usually indicates late stage (tertiary) syphilis.

Blood screening tests, such as VDRL and RPR, are more effective during middle stage (secondary) syphilis.

CSF test for syphilis

Reviewed last on: 7/27/2009
Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Hook EW III. Syphilis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 340.

Fletcher JJ, Nathan BR. Cerebrospinal fluid and intracranial pressure. In: Goetz, CG, eds. Textbook of Clinical Neurology. 3rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 26.

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