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CSF-VDRL test - Overview

Alternative Names

Venereal disease research laboratory slide test - CSF

Definition of CSF-VDRL test:

The CSF-VDRL test is used to diagnose neurosyphilis. This test looks for antibodies called reagins, which are sometimes produced by the body in reaction to the syphilis-causing bacteria.

How the test is performed:

The test is performed on a CSF sample obtained by lumbar puncture (spinal tap).

How to prepare for the test:

Before the procedure, you will be asked to review the risks and sign a consent form.

How the test will feel:

Usually, discomfort associated with the lumbar puncture is mild to moderate. The entire procedure usually takes about 30 minutes but may take longer. The actual fluid collection only takes a few minutes.

Why the test is performed:

The CSF-VDRL test is used to diagnose syphilis in the brain or spinal cord. Brain and spine cord involvement usually indicates late stage (tertiary) syphilis.

Blood screening tests, such as VDRL and RPR, are more effective during middle stage (secondary) syphilis.

CSF test for syphilis

Reviewed last on: 6/18/2007
Mark Levin, MD, Division of Infectious Disease, MacNeal Hospital, Berwyn, IL. Review provided by VeriMed Healthcare Network.

References

U.S. Preventive Services Task Force. Screening for Syphilis Infection: Recommendation Statement. Ann Fam Med 2004; 2: 362-365.

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