Definition of CSF total protein:

CSF total protein is a test to determine the amount of protein in cerebrospinal fluid (CSF). CSF is a clear fluid that circulates in the space surrounding the spinal cord. An abnormal protein level in the CSF suggests that there is an abnormal process occurring in the central nervous system.

How the test is performed:

The health care provider will place a needle into the lower spinal area and take a sample of cerebrospinal fluid. The entire procedure takes about 20 minutes. For detailed information, see the article on lumbar puncture.

The fluid is sent to a lab, where it is examined under a microscope.

How the test will feel:

Under experienced hands there should not be any pain. There may be a feeling of pressure when the needle is inserted but with appropriate anesthetic, this should not hurt. Occasionally, some people may feel numbness shooting down the leg. This may be due to irritation of a nerve root.

Why the test is performed:

Your doctor may order this test to help diagnose tumors, infection, inflammation of several groups of nerve cells, vasculitis, blood in the spinal fluid, or injury.