Normal Values:

A normal (negative) value means there are no abnormal cells present.

Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

What abnormal results mean:

Abnormal results are grouped as follows:

• ASCUS or AGUS (atypical cells of uncertain significance): These changes may be due to HPV infection, but may also mean there are precancerous changes.
• LSIL (low-grade dysplasia) or HSIL (high-grade dysplasia): This means precancerous changes are likely to be present; the risk of cervical cancer is greater with HSIL.
• Carcinoma in situ (CIS): This usually means the abnormal changes are likely to progress to cancer.
• Atypical squamous cells (ASC–H): This means abnormal changes have been found and may be HSIL.
• Atypical glandular cells (AGC): Cell changes are seen that suggest precancer of the upper part of the cervical canal or inside the uterus.

When a Pap smear shows abnormal changes, further testing or follow-up is needed. The next step depends on the results of the Pap smear, your previous history of Pap smears, and risk factors you may have for cervical cancer.

This may include:

• Colposcopy-directed biopsy
• An HPV test to check for the presence of the HPV virus types most likely to cause cancer

For minor cell changes, doctors usually recommend having a repeat Pap smear in 3-6 months.