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In myasthenia gravis, the muscles will improve immediately following the Tensilon. The maximum benefit only lasts a few minutes.
In myasthenic crisis (worsening of the disease that requires anticholinesterase therapy), there is a brief improvement in the muscle strength.
In cholinergic crisis (overdose of anticholinesterase), Tensilon will make the person even weaker.
Additional conditions under which the test may be performed include Lambert-Eaton syndrome.
Vincent A, Newsom-Davis J. Disorders of neuromuscular transmission. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 448.