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Kernicterus - Overview

Alternative Names

Bilirubin encephalopathy

Definition of Kernicterus:

Kernicterus is a rare neurological condition that occurs in some newborns with severe jaundice.

Causes, incidence, and risk factors:

Kernicterus is caused by very high levels of bilirubin. Bilirubin is a yellow pigment that is created in the body during the normal recycling of old red blood cells. High levels of bilirubin in the body can cause the skin to look yellow (which is called jaundice).

In some cases when there are extremely high levels of bilirubin in the body or the baby is extremely ill, the substance will move out of the blood and collect in the brain tissue. This can lead to serious neurological complications, including brain damage.

Kernicterus usually develops in the first week of life, but may be seen up until the third week. Newborns with Rh hemolytic disease that leads to hydrops fetalis are at high risk for severe jaundice that leads to this condition. However, kernicterus has been seen in apparently healthy babies.

Kernicterus

Reviewed last on: 10/11/2007
Deirdre O’Reilly, MD, MPH, Neonatologist, Division of Newborn Medicine, Children’s Hospital Boston and Instructor in Pediatrics, Harvard Medical School, Boston, Massachusetts. Review Provided by VeriMed Healthcare Network.

References

American Academy of Pediatrics, Subcommittee on Neonatal Hyperbilirubinemia: Neonatal jaundice and kernicterus. Pediatrics. 2001;108:763.

American Academy of Pediatrics, Subcommittee on Hyperbilirubinemia Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114: 297-316.

Behrman RE. Nelson Textbook of Pediatrics. 17th ed. Philadelphia, Pa: WB Saunders; 2004.

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