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Quad screen; Multiple marker screening; AFP plus; Triple screen test; AFP maternal; MSAFP; 4-marker screen
Normal levels of AFP, hCG, uE3, and inhibin A.
Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
An abnormal test result does NOT mean that your baby definitely has a birth defect. Often, the results can be abnormal if your baby is older or younger than the health care provider had thought. Common next steps by your doctor may include:
If abnormal results are still present, further testing and counseling can be done. Some individuals or couples choose not to have any more tests done, for personal or religious reasons. Possible next steps include:
During pregnancy, increased levels of AFP may be due to a problem with the developing baby, including:
High AFP can also mean that you' re carrying more than one baby.
Low levels of AFP and estriol and high levels of hCG and inhibin A may be due to a problem such as:
ACOG Committee on Practice Bulletins. ACOG practice bulletin no. 77: screening for fetal chromosomal abnormalities. Obstet Gynecol. 2007;109:217-227.
Anderson CL, Brown CEL. Fetal chromosomal abnormalities: Antenatal screening and diagnosis. Am Fam Physician. 2009:79(2).
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