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Colestasis inducida por medicamentos - Overview

Nombres alternativos

Colestasis inducida por fármacos

Definición:

Es una reducción del flujo de la bilis del hígado que resulta del uso de medicamentos.

Causas, incidencia y factores de riesgo:

La bilis se produce en el hígado, luego es transportada a la vesícula biliar a través de las vías biliares y excretada en los intestinos a través del tracto biliar. Ésta ayuda al cuerpo a digerir las grasas.

Ciertos fármacos pueden detener o disminuir el flujo de la bilis desde el hígado hasta la vesícula y los intestinos, lo cual puede dañar el hígado.

Muchos fármacos pueden causar colestasis, como:

  • Ampicilina y otros antibióticos a base de penicilina
  • Esteroides anabólicos
  • Clorpromazina
  • Cimetidina
  • Estolato de eritromicina
  • Estradiol
  • Sales de oro
  • Imipramina
  • Nitrofurantoína
  • Anticonceptivos orales
  • Proclorperazina
  • Sulindaco
  • Terbinafina
  • Tolbutamida
  • Reviewed last on: 5/4/2010
  • David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Afdhal NH. Diseases of the gall bladder and bile ducts. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 159.

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