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Síndrome de Wermer; NEM I
Es un trastorno hereditario en el cual una o más de las glándulas endocrinas son hiperactivas o forman un tumor. Las glándulas endocrinas más comúnmente involucradas abarcan:
La causa de la NEM I es un defecto en un gen que porta el código para una proteína llamada menina. La afección hace que muchos tumores de diversas glándulas aparezcan en la misma persona, pero no necesariamente al mismo tiempo.
El trastorno puede ocurrir a cualquier edad y afecta a hombres y mujeres por igual. Un antecedente familiar de este trastorno eleva el riesgo.
Kronenberg HM. Polyglandular disorders. in: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 250.
National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Neuroendocrine Tumors. National Comprehensive Cancer Network; 2009. Version 2.2009.
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