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Síndrome de Cushing ectópico - Overview

Nombres alternativos

Síndrome ectópico de Cushing

Definición:

Es una afección en la cual un tumor por fuera de la hipófisis o de las glándulas suprarrenales produce una hormona llamada corticotropina (ACTH, por sus siglas en inglés).

Causas, incidencia y factores de riesgo:

El síndrome de Cushing es el resultado del exceso de hormonas glucocorticoides liberadas por un largo período de tiempo. Aproximadamente el 15% de los casos de este síndrome se deben al síndrome de Cushing ectópico.

El síndrome de Cushing ectópico es causado por tumores que liberan hormona corticotropina (ACTH). Otras causas del síndrome de Cushing son:

  • Liberación excesiva de corticotropina por parte de la hipófisis
  • Uso prolongado de medicamentos corticosteroides (con frecuencia utilizados para el tratamiento de enfermedades como la artritis reumatoidea y el asma)
  • Tumor de la glándula suprarrenal

Los tumores que pueden, en casos raros, liberar corticotropina abarcan:

  • Reviewed last on: 3/18/2008
  • Elizabeth H Holt, MD, PhD, Assistant Professor of Medicine, Section of Endocrinology and Metabolism, Yale University. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Arnaldi G, Angeli A, Atkinson AB, et al. Diagnosis and complications of Cushing's syndrome: A consensus statement. J Clin Endocrinol Metab. 2003;88:5595-5602.

Stewart PM. The adrenal cortex. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR. Williams Textbook of Endocrinology. 11th ed. Philadelphia, PA: Saunders Elsevier; 2007:chap 14.

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