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Lupus eritematoso inducido por medicamentos - Overview

Nombres alternativos

Lupus farmacógeno o medicamentoso

Definición:

Es un trastorno autoinmunitario causado por una reacción a un medicamento.

Ver también: lupus eritematoso sistémico (LES)

Causas:

El lupus eritematoso inducido por fármacos (farmacógeno) es similar al lupus eritematoso sistémico (LES). Es un trastorno autoinmunitario, lo cual significa que el cuerpo ataca por error al tejido sano. Es causado por una reacción de hipersensibilidad a un medicamento.

Los medicamentos más comunes que se sabe que causan este tipo de lupus abarcan: isoniazida, hidralazina y procainamida. Otros medicamentos conocidos por causar el lupus farmacógeno son, entre otros:

  • Medicamentos anticonvulsivos
  • Capoten
  • Clorpromazina
  • Etanercept
  • Infliximab
  • Metildopa
  • Minociclina
  • Penicilamina
  • Quinidina
  • Sulfasalazina

Los síntomas tienden a ocurrir después de consumir el fármaco durante al menos 3 a 6 meses.

Las personas con lupus eritematoso inducido por fármacos pueden presentar síntomas que afecten las articulaciones (artritis), el corazón y los pulmones. Otros síntomas asociados con LES, como nefritis lúpica y enfermedad del sistema nervioso (neurológica), son poco comunes.

  • Reviewed last on: 6/28/2011
  • Ariel D. Teitel, M.D., M.B.A., Chief, Division of Rheumatology, St. Vincent’s Hospital, New York, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Wright B, Bharadwaj S, Abelson A. Systemic Lupus Erythematosus. In: Carey WD, ed. Cleveland Clinic: Current Clinical Medicine 2nd ed. Philadelphia, Pa: Saunders Elsevier; 2010.

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