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Mielofibrosis primaria

Definición:

Es un trastorno de la médula ósea en el cual la médula es reemplazada por tejido (cicatrizante) fibroso.

Nombres alternativos:

Mielofibrosis; Mielofibrosis idiopática; Metaplasia mieloide; Metaplasia mielocitoide agnógena

Causas, incidencia y factores de riesgo:

En la mielofibrosis primaria, se presenta una cicatrización progresiva (fibrosis) de la médula ósea y, como resultado, la sangre se forma en sitios diferentes a ésta, como el hígado y el bazo, causando un agrandamiento de estos órganos. La causa y los factores de riesgo se desconocen.

El trastorno se desarrolla generalmente con lentitud en individuos mayores de 50 años y lleva a que se presente insuficiencia progresiva de la médula ósea con anemia severa. El conteo de plaquetas bajo hace que se presente un fácil sangrado y que continúe el agrandamiento del bazo .

Referencias:

Hoffman R, Benz Jr. EJ, Shattil SJ, et al. Hematology: Basic Principles and Practice . 4th ed. Philladelphia, Pa: Churchill Livingston; 2005.

McPherson RA and Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. Philadelphia, Pa: WB Saunders; 2007:561-62.

Fecha de revisión: 2/26/2007
Versión en inglés revisada por: William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.
Traducción y localización realizada por: DrTango, Inc.

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