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Anticoagulantes lúpicos - Overview

Definición:

Son anticuerpos contra sustancias presentes en el revestimiento de las células que impiden la coagulación de la sangre en un tubo de ensayo. Estas sustancias se llaman fosfolípidos.

Las personas con estos anticuerpos pueden tener un riesgo anormalmente alto de coagulación sanguínea.

Ve también: anticuerpo.

Causas, incidencia y factores de riesgo:

Los anticoagulantes lúpicos generalmente se encuentran en personas con enfermedades autoinmunitarias, como el lupus eritematoso sistémico (LES).

Igualmente, se pueden encontrar en personas que toman ciertos medicamentos, como fenotiazinas, fenitoína, hidralazina, quinina y el antibiótico amoxicilina.

Las personas con enfermedad intestinal inflamatoria (enfermedad de Crohn y colitis ulcerativa), infecciones y ciertos tumores pueden tener anticoagulantes lúpicos.

Algunas personas no tienen factores de riesgo para esta afección. En algunos casos, puede estar ligada a un aumento del riesgo de coágulos sanguíneos y puede ser la causa de abortos espontáneos recurrentes.

  • Reviewed last on: 1/24/2011
  • Todd Gersten, M.D., Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Harris ED, Budd RC, Genovese MC, Firestein GS, Sargent JS, Sledge CB. Kelley's Textbook of Rheumatology. 7th ed. St. Louis, Mo: WB Saunders; 2005.

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