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Carencia del factor intrínseco - Overview

Nombres alternativos

Ausencia del factor intrínseco

Definición:

El factor intrínseco es una sustancia natural que normalmente se encuentra en el estómago y es necesaria para absorber la vitamina B12 de los alimentos.

Una carencia del factor intrínseco ocasiona anemia perniciosa y deficiencia de vitamina B12, lo cual puede causar anemia y problemas del sistema nervioso y del cerebro (neurológicos).

Causas, incidencia y factores de riesgo:

Los bebés que nacen sin el factor intrínseco no pueden absorber apropiadamente la vitamina B12, comenzando alrededor de los 6 meses de edad. Los niños que tienen el tipo juvenil de carencia del factor intrínseco tienden a mostrar signos y síntomas después de la edad de 10 años.

Los adultos mayores desarrollan anemia perniciosa, la cual es causada por una carencia en la producción del factor intrínseco. Esto por lo regular se debe a una enfermedad autoinmunitaria que ocasiona desgaste (atrofia) en el revestimiento del estómago, que es el lugar en donde generalmente se produce el factor intrínseco.

  • Reviewed last on: 1/31/2010
  • Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Antony AC. Megaloblastic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone; 2008:chap 39.

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