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Sobreproducción ovárica de andrógenos - Overview

Definición:

Esta afección se presenta cuando el ovario produce demasiada testosterona, estimulando el desarrollo de características masculinas. Otras hormonas, llamadas andrógenos, de otras partes del cuerpo también pueden causar el desarrollo de características masculinas en las mujeres.

Causas, incidencia y factores de riesgo:

En las mujeres sanas, los ovarios y las glándulas suprarrenales producen alrededor del 40 al 50% de la testosterona corporal. Tanto los tumores de los ovarios como el síndrome poliquístico (SPQ) pueden causar exceso en la producción de andrógenos.

La enfermedad de Cushing, una anomalía en la hipófisis, ocasiona cantidades excesivas de corticoesteroides, lo cual provoca cambios masculinos en las mujeres. Asimismo, los tumores en las glándulas suprarrenales pueden ocasionar sobreproducción de andrógenos y llevar a que se presenten características corporales masculinas en las mujeres.

Sobreproducción ovárica

Desarrollo del folículo

Reviewed last on: 6/7/2010
Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Lobo RA. Hyperandrogenism: physiology, etiology, differential diagnosis, management. In: Katz V, Lobo RA, Lentz G, Gershenson D, eds. Comprehensive Gynecology. 5th ed. Philadelphia, Pa: Mosby Elsevier; 2007:chap 40.

Bulun SE, Adashi EY. The physiology and pathology of the female reproductive axis. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 16.

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