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Una o ambas manos pueden resultar afectadas. El dedo anular resulta afectado con mayor frecuencia, seguido de los dedos meñique, del corazón y el índice.
Una pequeña protuberancia o nódulo indoloro se desarrolla en el tejido bajo la piel sobre el lado de la palma de la mano. Con el tiempo, éste se engruesa y forma una banda similar a un cordón.
Se vuelve difícil extender o enderezar los dedos. En casos graves, estirarlos es imposible.
El médico examinará sus manos. El examen físico de la palma de la mano mostrará tejido cicatricial grueso y dificultad para enderezar los dedos.
Stretanski MF. Dupuytren contracture. In: Frontera, WR, Silver JK, Rizzo TD Jr, eds. Essentials of Physical Medicine and Rehabilitation. 2nd ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 25.
Gilpin D, Coleman S, Hall S, Houston A, Karrasch J, Jones N. Injectable collagenase Clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease. J Hand Surg Am. 2010 Dec;35(12):2027-38.e1. PubMed PMID: 21134613.
Hurst LC, Badalamente MA, Hentz VR, et al; CORD I Study Group. Injectable collagenase clostridium histolyticum for Dupuytren's contracture. N Engl J Med. 2009 Sep 3;361(10):968-79. PubMed PMID: 19726771.
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