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Enfermedad granulomatosa crónica - Symptom

Nombres alternativos

EGC; Granulomatosis mortal de la infancia; Enfermedad granulomatosa crónica de la infancia; Granulomatosis séptica progresiva

Síntomas:

  • Infecciones en los huesos
  • Infecciones cutáneas frecuentes o difíciles de curar como:
    • abscesos
    • infección crónica dentro de la nariz
    • furúnculos
    • eccema impetiginizado (eccema complicado por una infección)
    • impétigo
    • abscesos perianales (abscesos alrededor del ano)
  • Infecciones en las articulaciones
  • Diarrea persistente
  • Neumonía
    • que ocurre frecuentemente
    • difícil de curar
  • Inflamación de los ganglios linfáticos en el cuello que se desarrolla de manera temprana en la vida, permanecen inflamados u ocurren con frecuencia. Los ganglios linfáticos pueden formar abscesos que requieren drenaje quirúrgico.

Signos y exámenes:

El examen físico puede mostrar un hígado agrandado (hepatomegalia), bazo agrandado (esplenomegalia) e inflamación de múltiples ganglios linfáticos en todo el cuerpo (adenopatía generalizada). Puede haber signos de infección ósea (osteomielitis) que algunas veces afecta múltiples huesos.

Una biopsia de tejido puede mostrar granulomas (grupos de fagocitos anormales).

Otros exámenes pueden abarcar:

  • Reviewed last on: 9/15/2010
  • David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Jatin M. Vyas, MD, PhD, Instructor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Boxer LA. Disorders of phagocyte function. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th Ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 129.

Glogauer M. Disorders of phagocyte function. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 175.

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