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El término "malignidad" (neoplasia maligna) se refiere a células cancerosas que tienen la capacidad de diseminarse a otros sitios en el cuerpo (hacer metástasis) o invadir y destruir tejidos. Estas células malignas tienden a tener un crecimiento rápido e incontrolable debido a cambios en su estructura genética.
Las células malignas que son resistentes al tratamiento pueden reaparecer después de haberse eliminado o destruido todos los restos detectables de ellas.
Moscow JA, Cowan KH. Biology of Cancer. In: Goldman L, Ausiello D. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 187.
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