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Significa que "afecta al cuerpo entero", en lugar de una sola parte o un solo órgano.
Por ejemplo, los trastornos sistémicos como la hipertensión o las enfermedades sistémicas como la gripe afectan a todo el cuerpo.
Una infección que está en el torrente sanguíneo se denomina infección sistémica; mientras que una infección que afecta solamente a una parte u órgano del cuerpo se llama infección localizada.
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