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Factor intrínseco - Overview

Definición:

Es una proteína producida por células en el revestimiento del estómago y es necesario para que los intestinos absorban la vitamina B12 de manera eficiente.

Información:

En una enfermedad llamada anemia perniciosa, el daño del sistema inmunitario al revestimiento del estómago puede ocasionar una falta (deficiencia) del factor intrínseco. Este tipo de anemia causa deficiencia de vitamina B12, lo cual lleva a un bajo conteo de glóbulos rojos (anemia).

Las deficiencias del factor intrínseco pueden ser causadas por otras razones, como:

  • Afecciones hereditarias
  • Otras enfermedades
  • Extirpación quirúrgica del estómago
  • Reviewed last on: 1/31/2010
  • Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Antony AC. Megaloblastic anemia. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 170.

Antony AC. Megaloblastic anemia. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 39.

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