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Examen de isoenzimas de la creatina-fosfocinasa - Results

Nombres alternativos

Isoenzimas de creatina-fosfocinasa; Isoenzimas de creatina-cinasa; Isoenzimas de CK

Significado de los resultados anormales:

Niveles de CPK-1 por encima de lo normal:

Debido a que la isoenzima CPK-1 se encuentra más que todo en el cerebro y los pulmones, una lesión a cualquiera de estas áreas puede incrementar sus niveles. El aumento en los niveles de esta isoenzima puede deberse a:

Niveles de CPK-2 por encima de lo normal:

Los niveles de CPK-2 aumentan de tres a seis horas después de presentarse un ataque cardíaco. Si no existe un daño posterior al miocardio, el nivel alcanza un pico entre 12 y 24 horas, y vuelve a su normalidad de 12 a 48 horas después de la muerte del tejido.

El aumento en los niveles de CPK-2 también pueden deberse a:

  • Lesiones por electricidad
  • Desfibrilación cardíaca (aplicación deliberada de choques al corazón por personal médico)
  • Trauma en el corazón (por ejemplo, por un accidente automovilístico)
  • Inflamación del músculo cardíaco debido generalmente a virus (miocarditis)
  • Cirugía a corazón abierto

Los niveles de CPK-2 generalmente no aumentan con dolor torácico causado por angina, embolia pulmonar (coágulo de sangre en el pulmón) o insuficiencia cardíaca congestiva.

Los niveles de CPK-3 por encima de lo normal generalmente son un signo de lesión o fatiga muscular y pueden deberse a:

  • Lesiones por aplastamiento
  • Lesión muscular debida a fármacos o inmovilización prolongada (rabdomiólisis)
  • Distrofia muscular
  • Miositis (inflamación de músculo esquelético)
  • Recibir múltiples inyecciones intramusculares
  • Examen de la función muscular y nerviosa reciente (electromiografía)
  • Crisis epiléptica reciente
  • Cirugía reciente
  • Ejercicio extenuante
  • Reviewed last on: 2/17/2011
  • David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Referencias

Anderson JL. ST segment elevation acute myocardial infarction and complications of myocardial infarction. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 72.

Barohn RJ. Muscle diseases. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 447.

Cannon CP, Lee TH. Approach to the patient with chest pain. In: Libby P, Bonow RO, Mann DL, Zipes DP, eds. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 49.

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