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Síndrome del recién nacido gris - Overview

Nombres alternativos

Intoxicación neonatal por cloranfenicol

Definición:

Es una afección peligrosa que se presenta en neonatos, especialmente en bebés prematuros, que han recibido el fármaco cloranfenicol.

Causas:

El cloranfenicol es un fármaco empleado para combatir infecciones bacterianas, entre ellas la meningitis. Sin embargo, si se administra a un recién nacido, este medicamento en altas dosis puede desencadenar una reacción de intoxicación potencialmente mortal.

Los bebés no tienen las enzimas (proteínas especiales en el cuerpo) necesarias para descomponer este fármaco. El fármaco se acumula en el torrente sanguíneo del bebé y puede llevar a que se presente:

  • Coloración azulada en labios, lechos ungueales y piel por la falta de oxígeno en la sangre(cianosis)
  • Muerte
  • Presión arterial baja
  • Reviewed last on: 12/7/2009
  • David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc., and Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine.

Referencias

Michelow IC, McCracken GH Jr. Antibacterial therapeutic agents. In: Feigin RD, Cherry JD, Demmler-Harrison GJ, Kaplan SL, eds. Feigin and Cherry's Textbook of Pediatric Infectious Diseases. 6th ed. Philadelphia, Pa: Saunders Elsevier; 2009:chap 248.

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