Muchos casos de necrosis aséptica no tienen una causa conocida, de tal forma que su prevención puede no ser posible. Sin embargo, en algunos casos, la persona puede reducir el riesgo haciendo lo siguiente:
Canale ST (ed). Campbell's Operative Orthopaedics. 10th ed. Philadelphia, Pa: Mosby; 2003.
Lackner H, Benesch M, Moser A, Smolle-Juttner F, Linhart W, Raith J, Urban C. Aseptic osteonecrosis in children and adolescents treated for hemato-oncologic diseases: a 13-year longitudinal observational study. J Pediatr Hematol Oncol. 2005 May;27(5):259-63.
Powars DR, Chan LS, Hiti A, Ramicone E, Johnson C. Outcome of Sickle Cell Anemia: A 4-Decade Observational Study of 1056 Patients. Medicine (Baltimore). 2005 Nov;84(6):363-376.
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