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A fin de mantener la sangre oxigenada y circulando durante la cirugía, se emplean tubos para desviar la sangre a la máquina de derivación corazón-pulmón.
Se extraen los pulmones del paciente y los pulmones del donante son suturados en su sitio. Se insertan tubos de drenaje para drenar el aire, el fluido y la sangre del tórax durante varios días y permitir que los pulmones se vuelvan a expandir por completo.

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