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Puede recomendarse un trasplante combinado de corazón y pulmón a pacientes que tengan enfermedad cardíaca y pulmonar.
Las razones más comunes para un trasplante combinado de corazón y pulmón son hipertensión pulmonar, fibrosis quística, enfermedad pulmonar asociada con daños al ventrículo derecho del corazón y varios defectos congénitos del corazón y los pulmones.

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