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La mayoría de las fisuras anales se puede tratar con éxito utilizando medidas tradicionales, como reblandecedores fecales y baños de agua tibia. El objetivo es permitir que el esfínter anal se relaje y, de esta manera, dejar que cicatrice la fisura. Si estos métodos no resultan efectivos, es necesario realizar una cirugía denominada esfinterotomía interna. Este procedimiento consiste en cortar parcialmente el esfínter anal, permitiendo que se relaje y, por lo tanto, facilitando la cicatrización de la fisura.

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