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La reducción de mamas por lo general se realiza en mamas grandes (macromastia), pero también puede indicarse en caso de:
Infecciones quísticas de la mama (mastitis poliquística)
Dolor de espalda, cuello, hombros, senos o cabeza
Pérdida de la sensibilidad en la mama, los brazos o dedos
Problemas al dormir o postura defectuosa como resultado del gran tamaño de las mamas
Surco pigmentado por el brassiere
Estrías (líneas similares a una cicatriz) en las mamas
Se requieren mamogramas (radiografías de mama) y exámenes de rutina de mama antes de la cirugía.

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